Endocrine Abstracts

Background: Gastric Bypass surgery (Bypass) is recognized as the ultimate metabolic surgery. The success in type 2 Diabetes (DM2) remission documented in patients submitted to Vertical Sleeve Gastrectomy (Sleeve) made questionable the hypothesis that this restrictive surgery has beneficial metabolic effects.Main goal: Comparing the Bypass and Sleeve’s efficacy in DM2 remission.Methods: Retrospective study of 112 diabetic patie...

BackgroundAlthough rare, hypoglycaemia in patients without history of diabetes should be recognized and studied, in order to reduce associated morbidity. Cotrimoxazole (TMP/SMX) is commonly used in clinical practice and hypoglycaemia is a rare side effect associated with its use. Literature advocates that this effect is due to the fact that SMX has the same sulphanilamide structural group of sulfonylurea, mimicking the hypoglycaemic effect by stimulating...

Introduction: MEN1 is a rare autosomal dominant syndrome typically characterized by neoplastic lesions of parathyroid glands, anterior pituitary gland and endocrine pancreas. Several other tumours are associated with this syndrome, including adrenal lesions, but their prevalence and clinical characteristics (endocrine secretion and aggressiveness) are largely unknown.Objective: To determine the prevalence, clinical characteristics and the possible genoty...

Introduction: The microvascular complications of diabetes and consequent autonomic neuropathy may cause changes in saliva’s secretion and composition. Hyperglycemic levels can also contribute to various oral pathological changes due to alteration of fungi or bacterial flora and dental biofilm surface, leading to the onset of candidiasis, periodontitis and dental caries. The aim of this study was to determine total bacterial load of saliva and dental biofilm of diabetic pa...

Introduction: Evidence implicates oxidative stress as mediator of diabetic complications. Furthermore, glucose variability (GV) is associated with oxidative stress and inflammation; however, association between GV and diabetes complications remains to be established. Our aim was to assess GV in patients with and without microvascular complications (MVC).Methods: We analysed 2454 and 6593 h of continuous glucose monitoring of patients with type 1 diabetes...

Introduction: Despite being a psychiatric disorder, anorexia nervosa (AN) is associated to severe systemic complications. The endocrine complications of AN are an opportunity for the diagnosis and treatment of this condition. The authors report the experience of the Endocrinology Department in the treatment of AN in inpatient setting.Patients and methods: Retrospective analysis of 45 patients admitted with AN between 2001 and 2015 in the Endocrinology de...

Introduction: Multiple endocrine neoplasia type 1 (MEN 1) is a rare syndrome with autosomal dominant inheritance. It mainly involves the parathyroid glands (90%), the pancreas (60%) and the pituitary (40%). More than 300 different MEN1 germline mutations were already described.Objective: To characterize families with MEN1 followed at the Department of Endocrinology of the University and Hospital Center of Coimbra, Portugal, from 1990 until 2015.<p cl...

Introduction: Definitive diagnosis of lymphocytic hypophisitis (LH) lacks a pathological analysis. The detection of pituitary antibodies (PAB) with the current methods presents variable results and its clinical utility is therefore limited. Recently, new methods were released for the interpretation of indirect immunofluorescence (IIF), which can increase the specificity for detection of PAB.Methods: We evaluated four patients followed in endocrinology co...

Background: Residual C-peptide (CP) secretion has been associated with better glycemic control in patients with type 1 diabetes (T1D).Aim: To evaluate how residual fasting CP (fCP) secretion impacts glycemic control in T1D and to identify possible confounding factors.Methods: A retrospective analysis of adult patients with T1D followed in our department that had their fCP and glucose levels obtained on the same blood sample during ...

Background: The use of Flash Glucose Monitoring (FGM) for the management of type 1 diabetes mellitus (T1D) is rapidly increasing.Aims: To assess the longitudinal evolution of glycated haemoglobin (HbA1c) and body mass index (BMI) with the use of FGM in patients with T1D; to determine predictive factors of benefit with the use of this technology.Materials and methods: Retrospective study of T1D patients, using FGM ≥6 months an...